Your ICA Listner settings do not stay applied.When you make a change to the ica listner in the remote session host configuration, then settings only stay applied for between 30 to 60 minutes. Here is the fix
On a fresh Exhange 2013 install you cannot log into the ECP/EAC and receive the error Server Error in ‘/owa’ Application. The Active Directory user wasn’t found.
Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.